Biolegend, 740795, LEGENDplex™ Human Neuroinflammation Panel 1 (13-plex) with Filter Plate

Neuroinflammation is the inflammation of neuronal tissue due to acute brain injury, protein aggregation, infectious processes, or genetically inherited disorders. Glial cells of the central nervous system produce both pro- and anti-inflammatory factors to modulate the progression of this immune response. In the event of neuronal damage, proteins may also be released into the surrounding cerebrospinal fluid. Neuroinflammation contributes to many neurodegenerative conditions, such as Alzheimer's and Parkinson's disease, as well as permeability disruptions of the blood-brain barrier. Accurate measurement of the cytokines, chemokines, growth factors, and neuronal disease biomarkers that underlie the complex process of neuroinflammation is critical to furthering understanding these pathologic disorders. The LEGENDplex™ Human Neuroinflammation Panel 1 (13-plex) is a bead-based multiplex assay panel, using fluorescence-encoded beads suitable for use on various flow cytometers. It allows for simultaneous quantification of 13 key targets involved in neuroinflammation such as VILIP-1, CCL2 (MCP-1), sTREM-2, BDNF, TGF-β1, VEGF, IL-6, sTREM-1, β-NGF, IL-18, TNF-α, sRAGE, CX3CL1 (Fractalkine). This assay panel provides higher detection sensitivity and broader dynamic range than traditional ELISA methods. The panel has been validated for use on cell culture supernatant, serum, and cerebrospinal fluid. The LEGENDplex™ Human Neuroinflammation Panel 1 (13-plex) is designed to allow flexible customization within the panel. Please visit www.biolegend.com/legendplex for more information on how to mix and match within the panel. This assay is for research use only.