Biolegend, 741309, LEGENDplex™ Human TNFSF Family Panel 1 (12-plex) w/VbP

TNFSF ligands and receptors work together and play pivotal roles in the modulation of cellular functions. They are essential for many developmental, homeostatic and stimulus-responsive processes. They are also involved in cellular differentiation, survival, programmed death, and more importantly, the immune response. TNFSF ligands are linked to many human diseases, especially chronic inflammatory diseases, autoimmune diseases, and cancer. The LEGENDplex™ Human TNFSF Family Panel 1 is a bead-based multiplex assay, using fluorescence-encoded beads suitable for use on various flow cytometers. This panel allows simultaneous quantification of 12 human TNFSF family ligands: OPG, APRIL (TNFSF13), TRAIL (TNFSF10), sCD40L (TNFSF5), TWEAK (TNFSF12), LIGHT (TNFSF14), FasL (TNFSF6), RANKL (TNFSF11), TNF-a (TNFSF2), TNF-b (TNFSF1), BAFF (TNFSF20), CD30L (TNFSF8). This panel provides higher sensitivity and broader dynamic range than the traditional ELISA method. The panel has been validated for use on serum and cell culture supernatant samples. A LEGENDplex™ Mix and Match system is available to customize assays for specificities within this TNFSF Family panel.