Biolegend, 741415, LEGENDplex™ NHP Anti-Virus Response Panel (13-plex) w/ VbP

Non-human primates (NHPs) are phylogenetically close to humans and often have been used as models to study viral vaccine efficacy and antiviral therapeutic safety and efficacy. In response to pathogens, especially viruses, cells release interferons and other cytokines to fight the infections. Interferons are typically divided into three types: 1 (e.g., INF-α, IFN-β), 2 (e.g., IFN-γ), and 3 (e.g., IFN-λ1, IFN-λ2). All interferons are important for fighting viral infections and for regulating the immune system. In addition, interferons are critically involved in cancer and autoimmune diseases such as psoriasis, systemic lupus erythematosus, and multiple sclerosis. Studying the expression profile of interferons and other related cytokines is pivotal to understand the immune responses against pathogens and related disease processes. The LEGENDplex™ NHP Anti-Virus Response Panel is a multiplex bead-based assay suitable for use on various flow cytometers. This panel allows simultaneous quantification of 13 NHP cytokines, including interferons (α, β, γ, λ1, and λ2/3), interleukins (1β, 6, 8, 10, 12), TNF-α, IP-10 and GM-CSF. This panel provides higher sensitivities and broader dynamic ranges than traditional ELISA methods. The panel has been validated for use on serum/plasma and cell culture supernatant samples. A LEGENDplex™ Mix and Match system is available to customize assays for specificities within this NHP Anti-Virus Response Panel.