Biolegend, 741537, LEGENDplex™ Human Inflammation Panel 3 (14-plex) w/ FP

Inflammation is the body's protective biological response to harmful stimuli such as pathogens, damaged cells, or irritants. It involves a complex cascade of immune and molecular events, where various molecules work together to initiate, amplify, regulate, and ultimately resolve the inflammatory process. Dysregulation of these molecules contributes to the development of autoimmune diseases, chronic inflammation, sepsis, cancer, and tissue injury. Moreover, their combined expression and signaling profiles serve as valuable biomarkers for assessing disease severity and progression. The LEGENDplex™ Human Inflammation Panel 3 (14-plex) is a bead-based multiplex assay, using fluorescence-encoded beads suitable for use on various flow cytometers. This panel allows simultaneous quantification of 14 key targets involved in inflammation and immune response such as CD14, IL-6Rα (CD126), CD163, TSG6, CHI3L1 (YKL-40), IL-18BP, S100A8, OPG (TNFSF11B), RANKL (TRANCE), IL-18Rα (CD218a), CD30, TWEAK (TNFSF12), HMGB1, MRP-14 (S100A9). This assay panel provides higher sensitivity and broader dynamic range than traditional ELISA methods. The panel has been validated for use on cell culture supernatant, serum, and plasma samples.