Biolegend, 787604, Recombinant Human APP770 (carrier-free)

Amyloid precursor protein (APP) is a cell surface receptor and transmembrane precursor protein expressed in neuronal cells. On the neuron surface, it is involved in a neurite growth, adhesion, and axonogenesis (1). It also participates in transcriptional regulation through protein-protein interactions. While the APP695 isoform is predominantly expressed in neurons, the APP751 and APP770 are found in non-neuronal cells. APP751 and APP770 both contain a Kunitz serine protease inhibitor domain and show identity to protease nexin-II (2). APP can be cleaved by α-, β-, and γ- secretases to generate soluble peptides with a host of different characteristics, including antimicrobial properties (3). The peptides formed from β- and γ- secretase cleavage consist of soluble APP beta and β-amyloid, which is the major component of plaque in Alzheimer’s disease. The soluble beta form of APP has been identified as a ligand for death receptor 6 (4). Soluble APP770 has been considered as a biomarker candidate of acute coronary syndrome. Plasma levels of sAPP770 are high in coronary arteria disease and these levels correlate with soluble form of CD40L a biomarker for platelet activation.