Biolegend, 791202, Recombinant Mouse NGFR (TNFRSF16)-Fc Chimera (carrier-free)

Select size of product is eligible for a 40% discount! Exclusions apply. Please contact your local BioLegend representative to receive a quote. Mouse nerve growth factor receptor (NGFR) is a type 1 transmembrane glycophosphoprotein of approximately 75 kD. It belongs to the low affinity neurotrophin receptor and tumor necrosis factor receptor superfamily. NGFR possesses an extracellular domain containing four 40 amino acid repeats with six cysteine residues at conserved positions, followed by a serine/threonine rich domain, a transmembrane, and an intracellular domain with 155 amino acids without kinase activity. Disruption of the cysteine-rich repeats leads to loss of ligand binding. NGFR induces different effects depending on its interaction with other proteins. Its interaction with sortilin induces apoptotic responses, while its interaction with Lingo-1 and Nogo-A participates in the myelin-dependent inhibition of axonal growth. Interaction with the neurotrophin tyrosine kinase receptors (Trks) promotes survival, axonal growth, and differentiation of neural cells. NGFR interaction with TrkA induces neural cell death, neurite growth, neuronal differentiation, and synaptic plasticity. The presence of NGFR/CD271 defines a subset of multipotential mesenchymal stromal cells derived from bone marrow. NGFR is identified as a marker of tumor initiating cells in human melanoma, esophageal carcinoma, hypopharyngeal carcinoma, and head and neck squamous cell carcinomas. In addition, NGFR has been associated with glioblastoma cell migration and invasion.