Biolegend, 803008, Biotin anti-β-Amyloid, 1-16 Antibody (Previously Covance catalog# SIG-39340)
500microl
Catalog Number: 803008
Send an RFQ.
Category
Loading…
| Verified Reactivity | Human |
|---|---|
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution; no preservatives or carrier proteins. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 1 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. |
| Application Notes | This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13. |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:
Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.
| Application References(PubMed link indicates BioLegend citation) |
|---|
| Thakker DR, et al. 2009. Proc. Natl. Acad. Sci. USA. 106(11):4501-6. (IHC) PubMed Oddo S, et al. 2005. Proc. Natl. Acad. Sci. USA. 102(8):3046-51. (IHC-other) PubMed Herzig M, et al. 2004. Nat. Neuro. 7(9):954-959. (WB) PubMed Zheng Y, et al. 2012. PLoS One 6:39035. (IHC-F) PubMed Abramowksi D, et al. J Neurosci. 32:1273. (WB) PubMed Forny-Germano L, et al. 2014. J. Neurosci. 34:13629. (WB, IHC) PubMed Gowert NS, et al. 2014. PLoS One 2:e90523. (ICC, EM) PubMed Sandoval-Hernández A, et al. 2015. PLoS One. 10: 0145467. (IHC-F) Kumar R, et al. 2016. Brain. 139:174-92 (WB) Miyamoto T, et al. 2016. J. Biol. Chem. 291:1719-34. (WB) Saito S, et al. 2017. Acta Neuropathol. Commun. 5:26-9. (IHC-P) PubMed Omata Y, et al. 2016. Aging (Albany NY) 8(3):427. (IHC-P) PubMed Peng W, et al. 2016. Neurobiol. Dis. 93:215. (IHC-other) PubMed Mandler M, et al. 2015. PLoS One. e0115237. (WB, IHC, ELISA) PubMed |
| Product Citations | Alfonso S, et al. 2016. Sci Signal. 9: ra47. PubMed Sompol P, et al. 2021. Aging Cell. :e13416. PubMed Braun DJ, et al. 2023. PLoS One. 18:e0286495. PubMed Jiang Z, et al. 2022. Anesth Analg. 641:135. PubMed Karaahmet B, et al. 2023. Pharmaceutics. :15. PubMed Mateus A, et al. 2017. Proc Natl Acad Sci U S A. 114:E6231. PubMed Chen JF, et al. 2021. Neuron. . PubMed Larson M, et al. 2012. J Neurosci. 32:10253-10266. PubMed Chiang ACA, et al. 2018. Am J Pathol. 188:739. PubMed Sompol P et al. 2017. The Journal of Neuroscience. 37(25):6132-6148 . PubMed Osborne C, et al. 2018. J Cell Sci. 131:. PubMed Sherman M, et al. 2016. J Neurosci. 36: 9647 - 9658. PubMed Zhou Z, et al. 2017. J Neuroinflammation. 14:75. PubMed Grant MKO, et al. 2019. PLoS One. 14:e0212815. PubMed Fitz NF, et al. 2020. Mol Neurodegener. 15:41. PubMed Chernick D, et al. 2018. J Neurochem. 147:647. PubMed Duncan MJ, et al. 2019. Alzheimers Dement (N Y). 5:70. PubMed Carter A, et al. 2017. PLoS One. 12(2):e0172161. PubMed Lathuilière A, et al. 2016. Brain. 10.1093/brain/aww036. PubMed Thygesen C, et al. 2018. Front Cell Neurosci. 12:397. PubMed West E, et al. 2017. J Cell Sci. 130:3050. PubMed Metaxas A, et al. 2019. Front Cell Neurosci. 0.915277778. PubMed |
|---|
| RRID | AB_2564657 (BioLegend Cat. No. 803007) AB_2564658 (BioLegend Cat. No. 803008) AB_2564656 (BioLegend Cat. No. 803009) |
|---|
| Structure | Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD. |
|---|
| Distribution | Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle. Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus. |
|---|
| Function | The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent. |
|---|
| Biology Area | Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation |
|---|
| Molecular Family | APP/β-Amyloid |
|---|
| Antigen References | Kumar A, et al. 2015. Pharmacol. Rep. 67(2):195. Sadigh-Eteghad S, et al. 2015. Med. Princ. Pract. 24(1):1 Hampel H, et al. 2015. Expert Rev. Neurother. 15(1):83. Puig KL, et al. 2012. Exp. Gerontol. 48(7): 608. Selkoe DJ, et al. 2016. EMBO Mol. Med. 8(6):595. Walsh DM, et al. 2007. J. Neurochem. 101(5):1172. |
|---|
| Gene ID | 351 |
|---|
| UniProt | View information about beta-Amyloid 1-16 on UniProt.org |
|---|
| Clone | 6E10 |
|---|
| Regulatory Status | RUO |
|---|
| Other Names | AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein |
|---|
| Previously | Signet Catalog# 9340-02Signet Catalog# 9340-05Signet Catalog# 9340-10Covance Catalog# SIG-39340 |
|---|
| Isotype | Mouse IgG1, κ |
|---|
