Biolegend, 803009, Biotin anti-β-Amyloid, 1-16 Antibody (Previously Covance catalog# SIG-39340)
1ml
Catalog Number: 803009
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Formulation | Phosphate-buffered solution; no preservatives or carrier proteins. |
| Preparation | The antibody was purified by affinity chromatography. |
| Concentration | 1 mg/mL |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. |
| Application Notes | This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13. |
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| Application References(PubMed link indicates BioLegend citation) |
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| Thakker DR, et al. 2009. Proc. Natl. Acad. Sci. USA. 106(11):4501-6. (IHC) PubMed Oddo S, et al. 2005. Proc. Natl. Acad. Sci. USA. 102(8):3046-51. (IHC-other) PubMed Herzig M, et al. 2004. Nat. Neuro. 7(9):954-959. (WB) PubMed Zheng Y, et al. 2012. PLoS One 6:39035. (IHC-F) PubMed Abramowksi D, et al. J Neurosci. 32:1273. (WB) PubMed Forny-Germano L, et al. 2014. J. Neurosci. 34:13629. (WB, IHC) PubMed Gowert NS, et al. 2014. PLoS One 2:e90523. (ICC, EM) PubMed Sandoval-Hernández A, et al. 2015. PLoS One. 10: 0145467. (IHC-F) Kumar R, et al. 2016. Brain. 139:174-92 (WB) Miyamoto T, et al. 2016. J. Biol. Chem. 291:1719-34. (WB) Saito S, et al. 2017. Acta Neuropathol. Commun. 5:26-9. (IHC-P) PubMed Omata Y, et al. 2016. Aging (Albany NY) 8(3):427. (IHC-P) PubMed Peng W, et al. 2016. Neurobiol. Dis. 93:215. (IHC-other) PubMed Mandler M, et al. 2015. PLoS One. e0115237. (WB, IHC, ELISA) PubMed |
| Product Citations | Alfonso S, et al. 2016. Sci Signal. 9: ra47. PubMed Sompol P, et al. 2021. Aging Cell. :e13416. PubMed Braun DJ, et al. 2023. PLoS One. 18:e0286495. PubMed Jiang Z, et al. 2022. Anesth Analg. 641:135. PubMed Karaahmet B, et al. 2023. Pharmaceutics. :15. PubMed Mateus A, et al. 2017. Proc Natl Acad Sci U S A. 114:E6231. PubMed Chen JF, et al. 2021. Neuron. . PubMed Larson M, et al. 2012. J Neurosci. 32:10253-10266. PubMed Chiang ACA, et al. 2018. Am J Pathol. 188:739. PubMed Sompol P et al. 2017. The Journal of Neuroscience. 37(25):6132-6148 . PubMed Osborne C, et al. 2018. J Cell Sci. 131:. PubMed Sherman M, et al. 2016. J Neurosci. 36: 9647 - 9658. PubMed Zhou Z, et al. 2017. J Neuroinflammation. 14:75. PubMed Grant MKO, et al. 2019. PLoS One. 14:e0212815. PubMed Fitz NF, et al. 2020. Mol Neurodegener. 15:41. PubMed Chernick D, et al. 2018. J Neurochem. 147:647. PubMed Duncan MJ, et al. 2019. Alzheimers Dement (N Y). 5:70. PubMed Carter A, et al. 2017. PLoS One. 12(2):e0172161. PubMed Lathuilière A, et al. 2016. Brain. 10.1093/brain/aww036. PubMed Thygesen C, et al. 2018. Front Cell Neurosci. 12:397. PubMed West E, et al. 2017. J Cell Sci. 130:3050. PubMed Metaxas A, et al. 2019. Front Cell Neurosci. 0.915277778. PubMed |
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| RRID | AB_2564657 (BioLegend Cat. No. 803007) AB_2564658 (BioLegend Cat. No. 803008) AB_2564656 (BioLegend Cat. No. 803009) |
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| Structure | Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD. |
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| Distribution | Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle. Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus. |
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| Function | The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent. |
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| Biology Area | Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation |
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| Molecular Family | APP/β-Amyloid |
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| Antigen References | Kumar A, et al. 2015. Pharmacol. Rep. 67(2):195. Sadigh-Eteghad S, et al. 2015. Med. Princ. Pract. 24(1):1 Hampel H, et al. 2015. Expert Rev. Neurother. 15(1):83. Puig KL, et al. 2012. Exp. Gerontol. 48(7): 608. Selkoe DJ, et al. 2016. EMBO Mol. Med. 8(6):595. Walsh DM, et al. 2007. J. Neurochem. 101(5):1172. |
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| Gene ID | 351 |
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| UniProt | View information about beta-Amyloid 1-16 on UniProt.org |
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| Clone | 6E10 |
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| Regulatory Status | RUO |
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| Other Names | AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein |
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| Previously | Signet Catalog# 9340-02Signet Catalog# 9340-05Signet Catalog# 9340-10Covance Catalog# SIG-39340 |
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| Isotype | Mouse IgG1, κ |
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