Biolegend, 848005, APC anti-mouse P2RY12 Antibody
25microg
Catalog Number: 848005
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| Verified Reactivity | Mouse |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Mouse P2RY12. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. |
| Concentration | 0.2 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | FC - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Excitation Laser | Red Laser (633 nm) |
| Application Notes | View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research. Learn more about the validation testing we performed on clone S16007D by watching our Scientific Poster Video. |
Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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| Additional Product Notes | View more applications data for this product in our Scientific Poster Library. |
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| Product Citations | D'Alessandro G, et al. 2020. Eur J Immunol. 50:705. PubMed Wiedemann SJ, et al. 2022. Cell Metab. 34:991. PubMed Pradhan AK, et al. 2023. Transl Psychiatry. 332:13. PubMed Montilla A, et al. 2023. Cell Death Dis. 14:16. PubMed Wu X, et al. 2021. Elife. 10:. PubMed Nair S, et al. 2021. JCI Insight. 6:. PubMed Dionisio-Santos DA, et al. 2021. Front Neurosci. 15:758677. PubMed |
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| RRID | AB_2721468 (BioLegend Cat. No. 848005) AB_2721469 (BioLegend Cat. No. 848006) |
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| Structure | P2RY12 is a 347 amino acid protein with a molecular mass of 39.8 kD. |
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| Distribution | Tissue distribution: platelets, brain (microglia), lung, appendix, pituitary and adrenal glands. Cellular distribution: cell membrane and cytosol. |
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| Function | G-protein coupled receptor that inhibits the adenylyl cyclase second messenger system. |
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| Ligand/Receptor | ADP and ATP. |
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| Cell Type | Microglia, Platelets |
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| Biology Area | Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers |
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| Molecular Family | GPCR, Purinergic Receptors |
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| Antigen References | 1. Orr AG, et al. 2009. Nat. Neurosci. 12(7):872-8. |
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| Gene ID | 70839 |
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| UniProt | View information about P2RY12 on UniProt.org |
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| Clone | S16007D |
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| Regulatory Status | RUO |
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| Other Names | P2Y12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12 |
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| Isotype | Rat IgG2b, κ |
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