Biolegend, 853706, Biotin anti-Synapsin I/II/III Antibody
100microg
Catalog Number: 853706
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| Verified Reactivity | Human, Rat |
|---|---|
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Immunogen | Recombinant protein corresponding to amino acids 362-450 of human Synapsin I |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze. |
| Application | WB - Quality tested IHC-P - Verified |
| Recommended Usage | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.001 - 0.01 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.5 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. |
| Product Citations | Yasom S, et al. 2022. FASEB Bioadv. 4:408. PubMed |
| RRID | AB_2801203 (BioLegend Cat. No. 853705) AB_2801204 (BioLegend Cat. No. 853706) |
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| Structure |
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| Synapsin I is a 704 amino acid protein with an apparent molecular mass of ~74 kD. Synapsin II is a 582 amino acid protein with an apparent molecular mass of ~63 kD. Synapsin III is a 580 amino acid protein with an apparent molecular mass of ~63 kD. |
| Distribution | Tissue distribution: Mainly in the central nervous system. Also expressed in testis. Cellular distribution: Cytosol, nucleus, and plasma membrane. |
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| Function | Synapsins are involved in the regulation of synaptic vesicle fusion and neurotransmitter release at the presynaptic terminals. |
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| Interaction | CAPON (Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein), PKA |
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| Cell Type | Neurons |
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| Biology Area | Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology |
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| Molecular Family | Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis |
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| Antigen References | Greengard P, et al. 1993. Science. 259(5096):780 Milovanovic D, et al. 2017. Neuron. 93(5):995 Evergren E, et al. 2007. J. Neurosci. Res. 85(12):2648 |
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| Gene ID | 685368548224 |
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| UniProt | View information about Synapsin I/II/III on UniProt.org |
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| Clone | A17080A |
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| Regulatory Status | RUO |
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| Other Names | SYN, Synapsin, Synapsin I, Synapsin II, Synapsin III |
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| Isotype | Mouse IgG2b, κ |
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