Biolegend, 856507, Alexa Fluor® 488 anti-β-Amyloid, aggregated Antibody
25microg
Catalog Number: 856507
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| Verified Reactivity | Human |
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| Antibody Type | Monoclonal |
| Host Species | Rat |
| Immunogen | Recombinant human Abeta S26C dimer. |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Preparation | The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions. |
| Concentration | 0.5 mg/ml |
| Storage & Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Application | IHC-P - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1 - 5 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses |
| Excitation Laser | Blue Laser (488 nm) |
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| RRID |
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| AB_2814572 (BioLegend Cat. No. 856507) AB_2814573 (BioLegend Cat. No. 856508) |
| Structure | Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD. |
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| Distribution | Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, and muscle. Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus. |
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| Function | The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent. |
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| Interaction | Tau, prion, α2-macroglobulin, apoE and apoJ, toll-like receptor 2 (TLR2), TLR4, TLR6, and their co-receptors CD14, CD36, and CD47. |
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| Ligand/Receptor | Receptor for advanced glycation end products (RAGE), low-density lipoprotein receptor-related protein 1 (LRP1), glycoprotein 330 (gp330/megalin), P-glycoprotein. |
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| Biology Area | Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation |
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| Molecular Family | APP/β-Amyloid |
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| Antigen References | Selkoe DJ. 1994. Annu. Rev. Cell Biol 10:373-403. O'Brien RJ, Wong PC. 2011. Annu. Rev. Neurosci. 34:185-204. Chen GF, et al. 2017. Acta. Pharmacol. Sin. 38:1205-1235. |
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| Gene ID | 351 |
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| UniProt | View information about beta-Amyloid on UniProt.org |
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| Clone | A17171C |
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| Regulatory Status | RUO |
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| Other Names | Purified anti-β-Amyloid, AAA, ABETA, ABPP, AD1, APPI, APP, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide |
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| Isotype | Rat IgG2a, κ |
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