Biolegend, 943904, Alexa Fluor® 647 anti-EGR1 Antibody

EGR1 (early growth response protein 1) is a zinc transcription factor vital to numerous physiological processes including cell cycle, differentiation, proliferation, metabolism, DNA damage response, and apoptosis. It also functions in mitogenesis, tissue repair, fibrosis, inflammatory response and immune response through its regulation of neutrophil gene expression and association with immune response genes such as TNFα, VEGF, and matrix metalloproteinases. In the central nervous system, EGR1 functions as an immediate early gene (IEG) and is vital to neuronal function and signaling, synaptic plasticity, cognition, and memory formation. Activated by acute mechanical injury and vascular stress, EGR1 regulates multiple cardiovascular pathological processes including atherosclerosis, intimal thickening and vascular repair in response to vascular injury, ischemia, angiogenesis, and cardiac hypertrophy. EGR1 is essential to the development, homeostasis, and repair of connective tissues through its regulation of genes of the extracellular matrix. EGR1 is a component of some oncogenic pathways and stimulates tumor growth and proliferation in prostate and gastric cancers. It also regulates a variety of tumor suppressors such as p53, PTEN, NAG-1, and TGFβ1, contributes to DNA repair, and induces apoptosis of tumor cells, thus functioning in dual roles as both an oncogene and as a tumor suppressor.