Cytiva, ACBFSULPLC, Allegro Connect bulk fill system: PLC 208 VAC, software automation

Configurable to your needs, the system supports a wide range of liquid filter capsules and various filter combinations. The system can fill up to 320 containers with bulk drug substance, process buffer or cell culture media using preconfigured standard accessories. Designed to minimize process risk, the system dispenses product in a sterile single-use flow path, maintaining a closed process at all times. It automatically vents and wets liquid filters, along with performing filter integrity and manifold leak testing. Process risk is further minimized by a comprehensive validation package characterizing extractables as well as particulates, in accordance with current industry expectations. Uncontrolled risk and preventable product loss at any stage in the manufacturing process is unwelcome. This is accentuated at this critical stage in the process and highlights the need for an efficient, robust and versatile solution to the bulk filling process.