Description
General description
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a significant role in the immune response by promoting the activation and proliferation of T cells and natural killer (NK) cells. It is produced by macrophages and dendritic cells and is involved in the regulation of various immune functions, including the production of other cytokines such as interferon-gamma (IFN-γ). IL-18 contributes to the body′s defense against infections and is implicated in the pathogenesis of several inflammatory and autoimmune diseases.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Ultrasensitive SMC® Technology: Detects IL-18 at femtogram-level concentrations, with a lower limit of quantification (LLOQ) around 90 fg/mL, making it ideal for low-abundance cytokine profiling.
Wide Dynamic Range: Accurately quantifies IL-18 across a broad concentration spectrum, suitable for both baseline and elevated inflammatory states.
Track Inflammatory Signaling with Precision: IL-18 plays a key role in innate immunity and inflammasome activation; this kit helps detect subtle shifts in its expression.
Advance Research in Autoimmune and Infectious Diseases: Ideal for studying IL-18’s role in conditions like rheumatoid arthritis, Crohn’s disease, and viral infections.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 90 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 40-100,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 92% Plasma: 92%
Recovery: Serum: 99% Plasma: 95%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although IL-18 was detectable in mouse, rat, and feline samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
