Merck, 03505-100ML, 1,2-Dibromoethane

General description
1,2-Dibromoethane (EDB) is a water-soluble dihaloalkane that was widely used as a soil and grain fumigant. This led to the contamination of soil, surface, and groundwater with residual EDB. As it is a potent carcinogen and mutagen, many studies have been conducted to identify chemical reactions for its degradation in the environment.
Application
1,2-Dibromoethane can be used:
To generate vinyl bromide in situ, which can undergo a palladium-catalyzed cross-coupling reaction with aryl boronic acids to form functionalized styrene derivatives.
As a brominating agent of tertiary carbanions in sterically hindered molecules.
As a building block to synthesize 2-arylsulfonyl hydrazones, (±)-horsfiline and 7-oxo-2, 3-dihydro-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acids.