Merck, 159034-5G, Acetohydroxamic acid

General description
Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Application
Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
Acetohydroxamic acid was used:
to study the mechanism of complexation of iron (III) with acetohydroxamic acid
to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni
in urease inhibition studies
for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile