Merck, 208923-10MG, CaMKII Inhibitor XII

General description
A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708 ).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)