Merck, 21860-5G, CDI

General description
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. 1,1′-carbonyldiimidazole (CDI) is an alternative to highly toxic insidious poison phosgene and thus aligns with the principle "Designing Safer Chemicals". Click here for more information.
CDI serves as a powerful coupling reagent in peptide synthesis and organic chemistry.
Application
CDI (1,1′-Carbonyldiimidazole) can be used:
In the activation of malonic acid derivatives to prepare carbonyl imidazoles by mild decarboxylation.
In the activation of cellulose membranes for the development of immunosensors.
In the synthesis of substituted 1,3-oxazolo[4,5-d] pyridazinones.
As a reagent for the conversion of various hydroxamic acids to isocyanates by Lossen rearrangement.
In the synthesis of 1,3,4-oxadiazole derivatives , and peptide thioesters in water.
As an acylation agent for the synthesis of carbamates.

Other Notes
Reactive reagent for the activation of acids as imidazolides: synthesis of esters, amides, ketones etc. Reagent for immobilizing enzymes and affinity ligands; Carbonyl-transfer reagent for the synthesis of various heterocycles, some recent applications