Merck, 219372-5MG, Cathepsin G Inhibitor I

General description
A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and Ki = 63 nM). Weakly inhibits chymotrypsin (Ki = 1.5 µM) and does not have any significant inhibitory effect on thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).
A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC₅₀ = 53 nM and Ki = 63 nM]. Weakly inhibits chymotrypsin (Ki = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ >100 µM).
Biochem/physiol Actions
Target Ki: 63 nM for cathepsin G
Product does not compete with ATP.
Reversible: yes
Primary Target
cathepsin G
Cell permeable: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)