Merck, 235989-1L, Brij® L4

General description
Brij® L4 is a non-ionic surfactant. It comprises an alkyl (C12) tail attached to an oxyethylene headgroup.
Application
Brij® L4 has been used:
as a surfactant for the synthesis of copper(I) oxide (Cu2O) spherical nanoparticles using a microemulsion technique
as a non-ionic surfactant for preparing reverse micelles to synthesize Pt3Co alloy nanoparticles
as a surfactant to enhance the efficiency of interfacial coupling of hydrophobic materials and to make hydrogel

Biochem/physiol Actions
Brij® L4 exhibits amphiphilic properties. Brij L4 contains hydrophobic and hydrophilic regions that can form micelles and disperse hydrophobic drugs into the core of micelles. This in turn enhances drug solubility. Brij L4 also elicits a strong inhibitory effect against breast cancer resistance protein (BCRP) mediated drug efflux. It inhibits Taq adsorption better when compared to other commonly used surfactants. Brij L4 supports droplet polymerase chain reaction (PCR) in picoliter reaction volumes at standard Taq concentrations.
Legal Information
Brij is a registered trademark of Croda International PLC