Merck, 240931-50G, Saccharin

General description
The biodegradation of saccharin (2-sulfobenzoic acid imide), an artificial sweetening agent, was studied. It was also studied for its carcinogenic potential.
Application

Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).

Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

Biochem/physiol Actions
A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.