Merck, 310468-500G, Lithium chloride

General description
Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.
Application
Lithium chloride can be used as:
A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.
An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.
A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.

LiCl is also used with other reagents:
LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.
LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.

Features and Benefits
Easy to handle
Weak Lewis acid
Highly soluble in water

Other Notes
Go to Redi-Dri™ Product Listing 746460
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