Description
General description
A potent inhibitor of human neutrophil elastase (HNE).The inhibition results from cross-linking of catalytic residues His⁵⁷ and Ser¹⁹⁵ in the HNE in the presence of this inhibitor.
A potent irreversible inhibitor of human neutrophil elastase (HNE). Inhibition results from cross-linking of the catalytic residues His⁵⁷ and Ser¹⁹⁵.
Biochem/physiol Actions
Primary Target
Human neutrophil elastase (HNE)
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
MeOSuc-Ala-Ala-Pro-Ala-CMK
Navia, M.A., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 7.
Williams, H.R., et al. 1987. J. Biol. Chem.262, 17178.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)