Merck, 343536-5G, 1-Boc-piperazine

General description
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K₃PO₄ (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
Application
1-Boc-piperazine may be used in:
preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors