Merck, 404454-25G, (S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride

General description
(S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride is a metal-salen complex that can catalyze a variety of asymmetric transformations.
Application
Salen (Mn)-catalyzed asymmetric epoxidation of unfunctionalized olefins. High enantioselectivities and yields are obtained for a variety of substrates, especially cis-alkenes. A few applications include the synthesis of the taxol side chain and cis-1-amino-2-indanol. Jacobsen′s catalyst has also been used in the asymmetric α-hydroxylation of silyl enol ethers. Catalyst for the enantioselective epoxidation of a variety of olefins.
Reactant involved in:
Studies of intercalative binding with ct-DNA and radical scavenging antioxidant activity
Immobilization on phenoxy-modified zirconium poly(styrenephenylvinylphosphonate)
Synthesis of derivatvies for studies of conformational models of enantioselective reactions

Catalyst involved in:
Asymmetric epoxidation of olefins
Immobilization on ionic liquid modified mesoporous silica for oxidative kinetic resolution of racemic secondary alcohols†
Immobilization on diamine modified zirconium olig-styrenyl phosphonate hydrogen phosphate for epoxidation of styrene

Legal Information
Manufactured under license by Sterling Pharma Solutions Limited, using Jacobsen HKR technology.