Merck, 571024-5G, Chlorosulfonic acid

General description
Chlorosulfonic acid is a strong acid that is synthesized on an industrial scale by reacting sulfur trioxide and dry hydrogen chloride gas in an equimolar ratio. It can act as a sulfonating, dehydrating, oxidizing and chlorinating agent. It is reported to be a better electrophilic olefin cyclization agent in comparison to other sulfonic acids. Its infrared spectra in the solid, liquid and gaseous state have been recorded in the region 4000-400cm⁻¹.
Application
Chlorosulfonic acid may be used in the following processes:
Synthesis of di-n-butyl ammonium chlorosulfonate, a secondary amine ionic liquid.
To prepare sulfonated polyethersulfone (SPES) with enhanced hydrophilic property.
To attach sulfate group to silk fibroin for improving its anticoagulant ability.
As a catalyst to prepare substituted coumarin, via von Pechmann condensation between phenol and β-ketoester.
As a substitute to acid catalyst in Biginelli reaction to prepare 3,4dihydropyrimidines.

Packaging
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