Merck, 65943-5ML, N-Methyl-bis(trifluoroacetamide)

General description
N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.
Application
Reagent for introducing trifluoroacetyl group.
N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B₆ vitamers), and thiols.
Other Notes
Reagent for trifluoroacetylations under mild conditions
Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany