Merck, 70372-1KG, 1,4-Naphthoquinone

Application
1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents.
It can be used to synthesize:
3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole.
Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generated in situ from aldehydes and diethyl aminomalonate.
α,α-Difluoro-β-hydroxy ketone via ‘on water′ catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane.
2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity.

Additional appilcation include:
As an arylation reagent for the α-arylation of aldehydes.
As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.