Merck, 77386-5G-F, 2-Bromo-1-ethyl-pyridinium tetrafluoroborate

General description
2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine.
Application
2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:
The synthesis of N-methylated peptides in solution and solid phase.
The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.

Other Notes
Coupling reagent for peptide synthesis; less racemization and faster reaction than with other reagents;e.g. BOP, PyBrOP, PyClU, BTFFH, CMBI