Merck, 78181-10G, Phenylboronic acid

General description
Phenylboronic acid is a highly stable receptor ligand used in cross-coupling reactions and drug delivery.

Phenylboronic acid (PBA) is an organoboronic acid. It behaves as a molecular receptor that can attach to compounds containing cis-diol group. Microwave-assisted Suzuki coupling of aryl chlorides with phenylboronic acid in the presence of Pd/C (catalyst) and water (solvent) has been described. Palladium-catalyzed cross-coupling reaction of phenylboronicacid with haloarenes to afford biaryls has been reported.
Application
Phenylboronic acid may be employed in the following reactions:
Rhodium-catalyzed intramolecular amination.
Pd-catalyzed direct arylation.
Mizoroki-Heck and Suzuki-Miyaura coupling reactions catalyzed by palladium nanoparticles.
Palladium-catalyzed stereoselective Heck-type reaction.
Highly effective Palladium-catalyzed arylation Suzuki-Miyaura cross-coupling in water.

Phenylboronic acid may be employed as reagent in the preparation of:
Ni(II) pincer complex and Pd(II) pyridoxal hydrazone metallacycles as catalysts for the Suzuki-Miyaura cross-coupling reactions.
N-type polymers for all-polymer solar cells.
Novel series of potent and selective mTOR kinase inhibitors.
Inhibitors of lactate dehydrogenase against cancer cell proliferation.

Other Notes
Contains varying amounts of phenylboronic anhydride