Merck, 850356C-25MG, 4ME 16:0 PC

General description
Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis.
4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine is a synthetic lipid. It has ester linkages between acyl chains and glycerol backbone and also between the headgroup and glycerol backbone. This neutral lipids possess high steric asymmetry. It remains in fluid or viscous liquid crystalline state over a wide range of temperature.
Application
4ME 16:0 PC is suitable for use:
to study its phase behaviour and its interactions with the representative antimicrobial peptide PGLa from Xenopus laevis (peptidyl-glycylleucine-carboxyamide
to improve the mechanical stability of planar lipid bilayer membrane
to prepare giant unilamellar vesicles (GUVs)

Biochem/physiol Actions
4ME 16:0 PC/DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine can be used as a bilayer mimic for electrophysiological measurements. It is stable under mechanical stress but the ester linkages are liable to hydrolysis under acidic or alkaline conditions.
Packaging
5 mL Clear Glass Sealed Ampule (850356C-25mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850356C-500mg)
5 mL Clear Glass Sealed Ampule (850356C-200mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC