Description
Application
The NanoFabTx™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.
Features and Benefits
A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
Step-by-step protocols developed and tested by our formulation scientists
Flexible synthesis tool to create uniform and reproducible liposomes
Optimized to make liposomes around 100 nm with low polydispersity
Optimized lipid blend for DBCO-modified protein or antibody conjugation
Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Azide Lipid Mix can be used with the the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™ Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
