Description
Application
NanoFabTx™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.
Features and Benefits
A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
Flexible synthesis methods to create uniform and reproducible liposomes
Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
A lipid film hydration and extrusion protocol
A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany
