Merck, 94675-500MG, Valinomycin

Name: Valinomycin
Brand: Merck
SKU: 94675-500MG

Size:500 mg, Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid, ≥99.0% (TLC)

Available Catalog Numbers

94675-100MG 94675-10MG 94675-500MG

Catalog Number: 94675-500MG

Pricing

Send an RFQ.

View RFQ List

Category

Antibiotics & Antimycotics

Pack Size500 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: peptide
Valinomycin is a neutral cyclic dodecadepsi-peptide antibiotic, that has a 36-member ring.Valinomycin consists of twelve stereogenic centers that are made of three repeating sequences of a tetramer of D-α-hydroxyisovalericacid-D-valine-L-lactate-L-valine. It shows antibacterial, antitumor, antifungal, antiviral, and insecticidal properties. Valinomycin exerts its antiviral activity against human coronavirus OC43 (HCoV-OC43), severe acute respiratory syndrome coronavirus (SARS-CoV), and middle-east respiratory syndrome coronavirus (MERS-CoV).
Application
Valinomycin has been used as an internal standard in the cytotoxicity assay for the detection of cereulide produced by emetic Bacillus cereus. It has also been used in the measurement of the electrogenicity of bile salt/H⁺ antiport in Escherichia coli.
Biochem/physiol Actions
K⁺-selective ionophore which uncouples oxidative phosphorylation.
K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.
Valinomycin affects the ion transport behavior of mitochondrial systems.

Specifications

General

Web Name Suffix Override	≥99.0% (TLC), K+ ionophore, powder
NACRES	NA.32
PubChem Substance ID	329770374
UNSPSC Code	12352200
EC Number	217-896-6
MDL number	MFCD00005114
Beilstein/REAXYS Number	78657
InChI key	FCFNRCROJUBPLU-RPUZOQEISA-N
InChI	1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
SMILES string	CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
assay	≥99.0% (TLC)
form	powder
mp	187-190 °C
antibiotic activity spectrum	mycobacteria
mode of action	cell membrane \| interferes
storage temp.	2-8°C

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, 94675-500MG, Valinomycin

Send an RFQ.

General

Notice

More from Merck.

CombiTitrant 5

SUPELCOSIL™ ABZ+Plus HPLC Column

SUPELCOSIL™ LC-CN HPLC Column

SUPELCOSIL™ LC-NH2 HPLC Column

More from Merck.

CombiTitrant 5

SUPELCOSIL™ ABZ+Plus HPLC Column

SUPELCOSIL™ LC-CN HPLC Column

SUPELCOSIL™ LC-NH2 HPLC Column