Merck, A1410-25MG, Actinomycin D

Name: Actinomycin D
Brand: Merck
SKU: A1410-25MG

Size:25 mg, Actinomycin C₁, Actinomycin IV, Dactinomycin, from Streptomyces sp., ~98% (HPLC)

Available Catalog Numbers

A1410-100MG A1410-10MG A1410-25MG A1410-2MG A1410-5MG

Catalog Number: A1410-25MG

Pricing

Send an RFQ.

View RFQ List

Category

Antibiotics & Antimycotics

Pack Size25 mg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.
Chemical structure: peptide
Application
Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells.
Biochem/physiol Actions
Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
Preparation Note
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Disclaimer
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.

Specifications

General

UNSPSC Code	51282001
NACRES	NA.85
PubChem Substance ID	24890541
EC Number	200-063-6
Beilstein/REAXYS Number	605235
MDL number	MFCD00005033
InChI key	RJURFGZVJUQBHK-IIXSONLDSA-N
InChI	1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
SMILES string	CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O
biological source	Streptomyces sp.
assay	~98% (HPLC)
form	powder
optical activity	[α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
color	red to orange red, powder

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, A1410-25MG, Actinomycin D

Send an RFQ.

General

Notice

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent