Merck, A8937-5G, Adenosine 5′-triphosphate dipotassium salt hydrate

General description
Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.
Application
Adenosine 5′-triphosphate dipotassium salt hydrate has been used:
in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
as a component of energy solution for calibrating crude cell extract
to test its dependency with PK11195 in mediating autophagy

Biochem/physiol Actions
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems.
Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.
Disclaimer
For maximum stability, store as frozen solution at pH 3.5 to 6.8.