ApplicationAir- and moisture-tolerant, this (+)-PSI Reagent was developed in the
Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat#
ALD00602).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the
Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).
Learn more about PI and PSI reagentsOther NotesUnlocking P(V): Reagents for chiral phosphorothioate synthesisPSI on OpenFlaskLegal InformationPCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692