Merck, C1357-1G, Cholecalciferol

General description
Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin.
Application
Cholecalciferol has been used:
to induce arterial medial calcification (AMC) in mice
to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice)
to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture

Biochem/physiol Actions
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Vitamin D acts through a receptor that modulates the proliferation and differentiation of both normal and cancer cells.