Merck, C213040-5G, DMT-2′O-TBDMS-rC(ac) Phosphoramidite

Name: DMT-2′O-TBDMS-rC(ac) Phosphoramidite
Brand: Merck
SKU: C213040-5G

Size:5 g, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1, 1-dimethylethyl)dimethylsilyl]-cytidine, 3′-[2-cyanoethyl N, N-bis(1-methylethyl)phosphoramidite], configured for MerMade

Available Catalog Numbers

C213040-10G C213040-5G

Catalog Number: C213040-5G

Pricing

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Category

Nucleotides & Nucleosides

Pack Size5 g

TagsChemistry & Biochemicals Biochemicals Nucleosides & Nucleotides

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features:

Industry-standard 2′O-TBDMS protective group
Consistent lot-to-lot purity and performance
Compatible with deprotection methods based on methylamine or AMA
Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are btained with activator 42
Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
Manufactured under a certified ISO 9001 quality system

DMT-2′O-TBDMS-rC(ac) Phosphoramidite is configured for MerMade Synthesizers.

Specifications

General

NACRES	NA.51
PubChem Substance ID	329774950
UNSPSC Code	12352200
MDL number	MFCD09842111
InChI	1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5
InChI key	QKWKXYVKGFKODW-YOEDQOPESA-N
biological source	non-animal source (no BSE/TSE risk)
product line	Proligo Reagents
assay	≥99% (31P-NMR)
form	powder
technique(s)	oligo synthesis: suitable
impurities	≤0.3% water content (Karl Fischer)
color	white to off-white
<i>λ</i>	conforms (UV/VIS Identity)
suitability	conforms to structure for H-NMR
compatibility	configured for MerMade

Ordering

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Merck, C213040-5G, DMT-2′O-TBDMS-rC(ac) Phosphoramidite

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