Merck, C4461-1G, Colistin sulfate salt

Name: Colistin sulfate salt
Brand: Merck
SKU: C4461-1G

Size:1 g, Polymyxin E, ≥19, 000 IU/mg

Available Catalog Numbers

C4461-100MG C4461-1G

Catalog Number: C4461-1G

Pricing

Send an RFQ.

View RFQ List

Category

Antibiotics & Antimycotics

Pack Size1 g

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: peptide
Application
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii . It has been used to study hephrotoxicity in the rat kidney , and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa .
Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH .
Analysis Note
Freely soluble in water, practically insoluble in acetone and in ethanol (96%)
Other Notes
Keep container tightly closed in a dry and well-ventilated place.

Specifications

General

UNSPSC Code	51102829
eCl@ss	34050906
EC Number	215-034-3
NACRES	NA.85
MDL number	MFCD00146495
SMILES string	[S](=O)(=O)(O)O.N1[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C1=O)CCN)CCN)CC(C)C)CC(C)C)CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC(CC)C)CCN)[C@H](O)C)CCN)[C@H](O)C
InChI	1S/C53H100N16O13.H2O4S/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;1-5(2,3)4/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);(H2,1,2,3,4)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+;/m1./s1
InChI key	ZJIWRHLZXQPFAD-LRYSGCCDSA-N
Quality Level	200
biological source	microbial
assay	≥19000 IU/mg ((EP, dried substance))
form	powder
specific activity	≥19,000 IU/mg
storage condition	(Tightly closed. Dry.)

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.

Merck, C4461-1G, Colistin sulfate salt

Send an RFQ.

General

Notice

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent

More from Merck.

Superspher® 60 RP-8 LiChroCART™ 250-4

Superspher® 60 RP-select B LiChroCART™ 250-4

Aluminum chloride hexahydrate

Ninhydrin Reagent