Merck, C4780-25MG, Coenzyme A sodium salt hydrate

Application
Coenzyme A sodium salt hydrate has been used:
in the branch chain aminotransferase enzymatic assay and protein determination
in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Biochem/physiol Actions
Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.
Analysis Note
Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH