Merck, E8399-25UG, Eotaxin-3 human

Name: Eotaxin-3 human
Brand: Merck
SKU: E8399-25UG

Size:25 μg, CCL26, SCYA26, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Catalog Number: E8399-25UG

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Category

Growth Factors & Cytokines

Pack Size25 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Growth Factors & Cytokines

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids. It belongs to the small inducible cytokine subfamily A , which also includes eotaxin and eotaxin-2.
Biochem/physiol Actions
Also known as CCL26 or SCYA26; a human CC chemokine and a functional ligand for CC chemokine receptor 3; mature recombinant human eotaxin-3 demonstrates chemotactic activity for eosinophils.
Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases. As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma. Demethylation results in increased expression of this gene, which in turn influences allergic reactions. This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP. Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.32
MDL number	MFCD01867165
biological source	human
recombinant	expressed in E. coli
assay	>97% (SDS-PAGE)
form	lyophilized powder
potency	0.25-1.0 mg
mol wt	~8.2 kDa
packaging	pkg of 25 μg
storage condition	avoid repeated freeze/thaw cycles
technique(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
UniProt accession no.	Q9Y258
storage temp.	−20°C
Quality Level	200
Gene Information	human ... CCL26(10344)

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Merck, E8399-25UG, Eotaxin-3 human

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