Merck, EZHFGF23-32K, Human FGF-23 ELISA Kit

General description
Studies demonstrate that Fibroblast Growth Hormone-23 plays a critical role as a phosphate-regulating hormone. FGF-23 is responsible for the inhibition of renal tubular reabsorption of inorganic phosphorus and, consequently, the regulation of phosphorus homeostasis. FGF-23 mRNA is expressed in the brain, in the thymus at low levels, in dendritic cells, with the highest expression in osteocytes and osteoblasts during phases of active bone remodeling. Because circulating levels of FGF-23 are regulated by vitamin D and phosphorus, normal skeletal and soft tissue development require vitamin D and a functional vitamin D signaling pathway. Diseases resulting from aberrant FGF-23 expression include inherited forms of rickets, certain kidney diseases and phosphorus-related tumors.
Application
50µl sample size, 2-Step assay with <4hr incubation time.
Research Category
Stem Cell Research
Used to detect/quantify: FGF-23
Biochem/physiol Actions
The antibody pair used in this assay cross-reacts 0.01% to Human FGF- 21 and 0.01% to FGF-19.

No significant cross-reactivity has been observed to other human and rat molecules/hormones tested
Other Notes
Please contact Technical Service for linearity of dilution.
Disclaimer
For research use only. Not for use in diagnostic procedures.