Merck, F7301-25UG, Fibroblast Growth Factor-18 human

Name: Fibroblast Growth Factor-18 human
Brand: Merck
SKU: F7301-25UG

Size:25 μg, FGF-18, >95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

Catalog Number: F7301-25UG

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Category

Growth Factors & Cytokines

Pack Size25 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Growth Factors & Cytokines

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.
Biochem/physiol Actions
FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.
FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.
Stimulates the proliferation and activation of cells that express the FGF receptors.
Physical form
Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.
Analysis Note
The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

Specifications

General

UNSPSC Code	12352202
EC Number	201-064-4
NACRES	NA.32
MDL number	MFCD01867042
biological source	human
recombinant	expressed in E. coli
assay	>95% (SDS-PAGE and HPLC)
form	lyophilized powder
potency	≤0.5 ng/mL
mol wt	predicted mol wt 21.2 kDa
packaging	pkg of 25 μg
storage condition	avoid repeated freeze/thaw cycles
impurities	endotoxin, tested
UniProt accession no.	O76093
storage temp.	−20°C
Quality Level	200
Gene Information	human ... FGF18(8817)

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Merck, F7301-25UG, Fibroblast Growth Factor-18 human

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