Merck, GE17-5317-02, Capto™MMC

General description
Capto™ MMC is a multimodal cation exchanger with a different selectivity, compared with traditional ion exchangers. It can be used to bind proteins at the conductivity of the feed material and to solve specific purification challenges.

Capto™ MMC is a multimodal cation exchanger, belonging to the Capto™ family of BioProcess media for fast, efficient and cost-effective protein purification. Capto™ MMC combines agarose base matrix developments with innovative ligand chemistry. It is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The multimodal functionality gives Capto™ MMC a different selectivity, compared with traditional ion exchangers. It can be used to bind proteins at the conductivity of the feed material and to solve specific purification challenges at both high and low ionic strengths.

The ligand contains caroxylic group and thus its features partly resemble a weak cation exchanger, but for Capto™ MMC also several other types of interactions are involved, including hydrogen bonding and hydrophobic interactions.

Capto™ MMC is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, Capto™ MMC meets industrial demands with security of supply and comprehensive technical and regulatory support.
Dynamic binding capacity at 10% breakthrough as measured at a residence time of 2 min, 300 cm/h in a Tricorn 5/100 column with 10-cm bed height in 50 mM Sodium acetate, pH 4.75, 250 mM NaCl.
Features and Benefits
Multimodal cation exchanger with a novel selectivity.
High dynamic binding capacity at high conductivity increases productivity
High-volume throughput cuts process times
Smaller unit operations give cost-effective processing and reduce investments

Preparation Note
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
Store at 4 to 30 °C (20% Ethanol)
Analysis Note
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Legal Information
Capto is a trademark of Cytiva