Description
General description
"The SARS-CoV-2 coronavirus is the pathogenic cause of the human disease COVID-19. The virus particle consists of RNA encapsulated by the nucleocapsid (N) protein which is enveloped by a membrane (M) protein. The corona-like spike proteins surrounding this inner core consist of subunits S1, S2 and the receptor binding domain which binds to the human cellular ACE-2 receptor. Upon binding, the virus enters the cell, takes over the cellular machinery, reproduces, and the viral contagion continues. Viral structural proteins offer antigenic potential for an immune response. Upon viral infection the humoral immune system responds first by producing the immunoglobulin IgM, followed later by IgG which can convey long lasting immunity. IgA, a mucosal immune response, is also found in blood.By testing for IgM, IgG, and IgA in human serum and plasma, researchers may identify those who have been exposed to the SARS-CoV-2 virus and mounted some level of immune response. Researchers may further understand the immune response over the course of infection and recovery from COVID-19."MILLIPLEX® SARS-CoV-2 Antigen Panel 1 IgM is a 4-plex kit to be used for the simultaneous analysis of human serum or plasma samples for IgM antibodies which recognize any or all of the following analytes: SARS-CoV-2 Spike S1, SARS-CoV-2 Spike S2, SARS-Cov-2 RBD, Sars-CoV-2 N
Application
The SARS-CoV-2 Antigen Panel 1 IgM is a bead-based multiplex assay based on the Luminex® xMAP technology which enables the simultaneous analysis of human samples for IgM antibodies which recognize any of the following analytes: SARS-CoV-2 Spike S1, SARS-CoV-2 Spike S2, SARS-Cov-2 RBD, Sars-CoV-2 N.This is assay yields results in Median Fluorescence Intensity (MFI).Four assay control beads are included in the base kit.This is a one day assay.This assay requires 25 μL of 1:100 diluted plasma or serum.Analytes available:SARS-CoV-2 Nucleocapsid Protein (N);SARS-CoV-2 Receptor Binding Domain (RBD);SARS-CoV-2 Spike Protein Subunit 1 (S1);SARS-CoV-2 Spike Protein Subunit 2 (S2)
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Packaging
96-well plate
Preparation Note
Recommended storage for kit components is 2 - 8°C.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
