Description
General description
Metastasis is a complex process in which tumor cells leave the primary tumor site and migrate to other parts of the body via blood and lymph vessels or by tumor invasion of surrounding tissues and organs. Breaking away from the primary tumor, cancer cells attach to and degrade extracellular matrix proteins that separate tumor from surrounding tissues to escape into the stroma. Where metastases form often depends on the primary tumor. Bone metastases, for example, tend to arise from breast, prostate and kidney tumors. This organ/tissue specificity seems to involve chemical signals from both chemokines and growth factors.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 9 analytes in human serum, plasma, tissue/cell culture supernatants or lysate samples.
Analytes included: DKK-1, GDF-15, Neuron-specific Enolase (NSE), Osteonectin (SPARC), Osteoprotegerin (OPG), Periostin, TRAP5, TWEAK, YKL40 (CHI3L1)
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Comprehensive Biomarker Detection: The panel includes nine key metastasis biomarkers (DKK-1, GDF-15, NSE, Osteonectin, OPG, Periostin, TRAP5, TWEAK, YKL40) relevant to various tumor types.
Multiplex Detection Capability: Utilizes the Luminex®xMAP® platform in bead format to enable simultaneous quantitative analysis of multiple biomarkers, enhancing throughput and efficiency.
Flexible Sample Types: Compatible with human serum, plasma, and tissue/cell culture supernatants or lysates, providing versatility in sample collection.
Configurable Kit Design: Researchers can design their multiplex kit by selecting analytes tailored to their specific research needs.
Facilitates Understanding of Metastatic Mechanisms: By providing insights into the biomarkers associated with metastasis, the panel aids in understanding the complex processes of tumor cell migration and organ specificity.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
