Description
General description
Produced by plasma cells and lymphocytes, immunoglobulins (antibodies) are critically involved in immune response, attaching to antigens, and playing a role in their destruction. Immunoglobulins (Ig) can be classified by isotype, classes that differ in function and antigen response due to structure variability. Five major isotypes have been identified in placental mammals: IgM, IgG, IgA, IgE and IgD (B-cell receptor) – all found in normal individuals. Immunoglobulin-deficiency disorders, such as autoimmune disease, some GI conditions, and malignancies, are characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of immunoglobulin classes. In addition, isotyping applications include analyzing hybridomas during antibody generation and vaccine development.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cell culture supernatants.
Analytes included: IgG1, IgG2, IgG3, IgG4, IgA, IgM
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Comprehensive Isotyping: Measures multiple human immunoglobulin classes and subclasses (IgG1, IgG2, IgG3, IgG4, IgA, IgM) in a single assay, providing a complete overview of the immune response.
Enhanced Research Capabilities: By providing a detailed analysis of immunoglobulin isotypes, researchers can better understand immune responses in various conditions, including autoimmune diseases and malignancies.
Quick Turnaround: Assay run time of just one day allows for timely results, facilitating faster research progress.
Standardization and Controls: Includes multi-immunoglobulin standard and positive control to ensure assay reliability and accuracy.
Increased Productivity: The multiplex nature of the assay significantly reduces the time and resources needed to assess multiple analytes, allowing researchers to focus on data interpretation and application.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
