Merck, I4026-25UG, Interleukin-17 from mouse

Name: Interleukin-17 from mouse
Brand: Merck
SKU: I4026-25UG

Size:25 μg, CTLA-8, IL-17, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Catalog Number: I4026-25UG

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Category

Growth Factors & Cytokines

Pack Size25 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Growth Factors & Cytokines

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Biochem/physiol Actions
IL-17 (interleukin-17) participates in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways and CCAAT/enhancer-binding protein family of transcription factors, thereby regulating pro-inflammatory and antimicrobial genes. In rheumatoid arthritis, IL-17 is responsible for the inflammation as well as destruction of joints.
Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.
Analysis Note
The biological activity of mouse IL-17 is measured by its ability to induce IL-6 production using NIH/3T3 cells.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.32
MDL number	MFCD01635117
biological source	mouse
recombinant	expressed in E. coli
assay	≥97% (SDS-PAGE)
form	lyophilized powder
mol wt	16.5 kDa
packaging	pkg of 25 μg
technique(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
UniProt accession no.	Q62386
storage temp.	−20°C
Quality Level	200
Gene Information	mouse ... Il17a(16171)

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Merck, I4026-25UG, Interleukin-17 from mouse

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