Merck, I9381-10MG, Isovaleryl coenzyme A lithium salt hydrate

General description
Isovaleryl coenzyme A is an intermediate in leucine catabolism. Iv-CoA is synthesized from β-methylbutyric acid by the action of enzyme acyl CoA synthetase. The conversion of isovaleryl-CoA to methylcrotonyl-CoA is catalyzed by the enzyme isovaleryl-CoA dehydrogenase in leucine catabolism pathway. The enzyme isovaleryl-CoA oxidase also calalyzes this conversion in fatty acid β-oxidation pathway.
Application
Isovaleryl coenzyme A (IV-CoA ) lithium salt hydrate may be used:
as substrate for β-Hydroxy-β-methylbutyric acid synthesis in cell-free extracts from G. reessii
in high-performance liquid chromatography (HPLC) for the characterization of IV-CoA from lymphocytes
as a substrate in isovaleryl-CoA dehydrogenase assay